Let's go deeper into the problem. Children seems to suffer more widely than adults. Also one problem is duet to so many changes in their bodies, their growing and the imunne system is still developing. How can we help them?
Neonatal (NLE) and Pediatric Lupus (pSLE) can be divide into several categorizes or types: cutaneous lupus (LE), Bullous Lupus (BSLE) of children and adolescents. This seems to be quite huge and complicated topic. If I have been lost in terms before this is completely different level now.
Children with lupus may have hematologic abnormalities. Patients with imunne disease in the kidneys may have nephritis or nephrotic syndrome. Also patients may experience neurological problems, from psychosis to cognitive disorders. Do not forget on pulmonary diseases and cardiac diseases. No organ is safe.
As NLE usually manifests as non scarring, non atrophy producing lesions similar to cutaneous Lupus (LE), others as BSCLE and ACLE are producing lesions.
BSLE has typical sub epidermal blistering and occurs to patients with SLE. To be diagnosed with BSLE patients experience vesiculose eruptions of blisters, and evidence of antibodies.
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| Purple candle for May as a Lupus awareness month!! |
Neonatal (NLE) and Pediatric Lupus (pSLE) can be divide into several categorizes or types: cutaneous lupus (LE), Bullous Lupus (BSLE) of children and adolescents. This seems to be quite huge and complicated topic. If I have been lost in terms before this is completely different level now.
Children with lupus may have hematologic abnormalities. Patients with imunne disease in the kidneys may have nephritis or nephrotic syndrome. Also patients may experience neurological problems, from psychosis to cognitive disorders. Do not forget on pulmonary diseases and cardiac diseases. No organ is safe.
As NLE usually manifests as non scarring, non atrophy producing lesions similar to cutaneous Lupus (LE), others as BSCLE and ACLE are producing lesions.
BSLE has typical sub epidermal blistering and occurs to patients with SLE. To be diagnosed with BSLE patients experience vesiculose eruptions of blisters, and evidence of antibodies.
Lupus is a connective tissue disease associated with polyclonal B-cell activation and it is believed to be a result from genetic, environmental and hormonal conditions. The disease vary in different level from patient to patient.
SLE - specifically to skin diseases (LE) can be classified into 3 subsequent categories: acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and chronic cutaneous lupus (CCLE) that is also known as discoid lupus (DLE), see the drawing (credit to Medscape).
ACLE is typical for a strong butterfly rash and strong photosensitive dermatitis and last for several days to weeks. Usually lesions are non scarring.
Almost all children need corticosteroids and immunosuppressive drugs. There are not many statistics made for children but it seems for example that gender ratio female to male changes with age. The SLE was also found in children under 2 years of age. The ratio is around 4:3. If the onset of the disease occurs by the end of the first decade it seems rather 4:1 and continues to 9:1 during the second decade. I think it should be related to hormones then. What do you think?
Have a nice day!!
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