Article on EB virus may trigger lupus

I have found an interesting article which was related to lupus causes. And I would like to write short resume on the topic. And because it is highly complicated I don't want to pretend to have any deeper knowledge. I am just trying myself to understand it.

Infection caused by Epstein Barr (EB) virus has been associated with subsequent lupus and other autoimunne disease development. So, EB virus protein may trigger some cases of lupus, but the mechanism was still unclear until now.

The EB virus is one of eight human herpesvirus types in the herpes family. It is one of the most common viruses and is best known as the cause of mononucleosis. Infection with EB virus occurs through oral transfer of saliva and genital secretion.  
EB virus is present almost everywhere in our population worldwide. We get in contact with it typically during the childhood and symptoms are usually easy going, cold like illness and it remains latent throughout the lives.



Now, scientists have shown mechanism how viral protein in EB virus human cells may activate genes which are associated with increased risk for autoimmunity:

When EB virus infects human imunne cells, a protein which is produced by the virus recruits human proteins. Both factors activate some of the human genes associated with risk for autoimunne diseases, such as lupus.

Uff, I hope it does make sense :-D.

Have a nice day and nice weekend, I feel quite exhausted!!


Comments

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